Arbutin CAS#497-76-7
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Daily Chemicals

Arbutin CAS#497-76-7

Arbutin, a derivative of hydroquinone, is a naturally occurring compound extracted primarily from the bearberry plant (Arctostaphylos uva-ursi). It is renowned in the skincare industry for its skin lightening properties, making it a popular ingredient in cosmetic products designed to reduce hyperpigmentation and even out skin tone. Chemically, arbutin is ??-glucosiduronic acid of hydroquinone, with the molecular formula C12H12O7. Its mechanism of action involves the inhibition of tyrosinase, a key enzyme in the melanin biosynthesis pathway. By reducing melanin production, arbutin effectively lightens the skin without the risk of irritation often associated with hydroquinone. Arbutin is valued for its safety profile, as it is considered less irritating and more stable compared to other skin lightening agents. It is also known for its antioxidant properties, which contribute to its skin brightening effects and overall skin health benefits. <p class="last-node">In summary, arbutin is a reliable and gentle alternative for skin lightening, offering a natural approach to reducing pigmentation issues while promoting a more radiant and even complexion. Its use in skincare formulations is favored for its efficacy and mildness, making it suitable for various skin types.</p>

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Arbutin CAS#497-76-7

Arbutin, a derivative of hydroquinone, is a naturally occurring compound extracted primarily from the bearberry plant (Arctostaphylos uva-ursi). It is renowned in the skincare industry for its skin lightening properties, making it a popular ingredient in cosmetic products designed to reduce hyperpigmentation and even out skin tone.

Chemically, arbutin is ??-glucosiduronic acid of hydroquinone, with the molecular formula C12H12O7. Its mechanism of action involves the inhibition of tyrosinase, a key enzyme in the melanin biosynthesis pathway. By reducing melanin production, arbutin effectively lightens the skin without the risk of irritation often associated with hydroquinone.

Arbutin is valued for its safety profile, as it is considered less irritating and more stable compared to other skin lightening agents. It is also known for its antioxidant properties, which contribute to its skin brightening effects and overall skin health benefits.

In summary, arbutin is a reliable and gentle alternative for skin lightening, offering a natural approach to reducing pigmentation issues while promoting a more radiant and even complexion. Its use in skincare formulations is favored for its efficacy and mildness, making it suitable for various skin types.

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Description

Melting point 195-198???C
Boiling point 375.31??C (rough estimate)
alpha -64 o (c=3)
density 1.3582 (rough estimate)
refractive index -65.5 ?? (C=4, H2O)
storage temp. Inert atmosphere,Room Temperature
solubility H2O: 50?mg/mL hot, clear
form Solid
pka 10.10??0.15(Predicted)
color White
optical activity [??]/D -64.0??2.0??, c = 3 in H2O
Water Solubility 10-15 g/100 mL at 20 oC
Sensitive Hygroscopic
Merck 14,773
BRN 89673
Stability: Stable. Hygroscopic – store under dry nitrogen.
InChIKey BJRNKVDFDLYUGJ-RMPHRYRLSA-N
LogP -1.350
CAS DataBase Reference 497-76-7(CAS DataBase Reference)
EPA Substance Registry System .beta.-D-Glucopyranoside, 4-hydroxyphenyl (497-76-7)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 22-24/25-36-26
WGK Germany 3
RTECS CE8863000
F 3-10-23
HS Code 29389090
Hazardous Substances Data 497-76-7(Hazardous Substances Data)

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